butabarbital will lessen the extent or outcome of zaleplon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.butabarbital will lessen the level or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.butabarbital will lessen the extent or outcome of eltrombopag by i